Giovanni Borgia, 2nd Duke of Gandia (1474 – June 14, 1497) was the son of Pope Alexander VI and the older brother of Cesare Borgia, Gioffre Borgia, and Lucrezia Borgia. Giovanni, also known as Juan or Joan,
Cesare, the second, was born September 1475 or April 1476. He was the son of Pope Alexander VI of Spain and his long-term mistress Vannozza dei Cattanei.
She had four husbands. First she married Domenico d'Arignano. Her second husband was Antonio de Brescia. In 1480 she married Giorgio della Croce. She had a son named Ottaviano with him. When she became a widow she finally married Carlo Canale.